A2M (Alpha-2-Macroglobulin) Therapy

What is A2M Therapy?

Alpha-2-Macroglobuilin (A2M) is found in the blood and is the major non-immunoglobulin protein found in plasma protein. This substance can be used to treat osteoarthritis symptoms and may impact the progression of the disease. Alpha-2-Macroglobuilin (A2M) binds to the chemicals produced in the joints that degrade cartilage over time and neutralizes their degenerative effect.

Alpha-2-Macroglobuilin (A2M) can:

  • Stop the breakdown of cartilage and prevent cartilage loss
  • Halt the progression of osteoarthritis
  • Reduce the pain caused by osteoarthritis
  • Improve joint function
  • Promote tissue growth
  • Support the restoration of the affected joint(s)
Alpha-2-Macroglobuilin (A2M)

How does the A2M injection work?

A2M injection an office procedure that can be completed in addition to PRP injection. Blood is drawn from the patient and then processed in a centrifuge. The spinning of the blood will separate out two different types of plasma. Once the plasma is separated it goes through and additional filtration process to be able to isolate the A2M. A concentrated dose of A2M will then be injected back into the problem joint or joints.

Patients generally feel no inflammation or pain after the injection. More importantly they often note improved pain and mobility in the injected joint. The time frame of relief can vary based on age, severity of osteoarthritis, and several other factors. The goal is limit pain and improve function for a significant period of time and possibly delay the need for any surgical procedures.

Centrifuge spinning blood for A2M Therapy.


To make an appointment, call the office directly at (303) 945-4790 or request one through our online Patient Portal.

Patient Portal

Main Office

12596 West Bayaud Ave
Suite 205
Lakewood, CO 80228

Phone: (303) 945-4790
Fax: (877) 861-0393 or
(720) 645-1959

Office Hours

Monday - Thursday
8:00am - 5:00pm